This report summarizes case study research based on three Indigenous Non-governmental Organisations (INGOs) in Canada having a transformative impact in their communities—Qqs Projects Society, Storytellers’ Foundation, and Ilisaqsivik Society. They are unique organizations that reflect distinct places, people, cultures, histories, and socioeconomic contexts. However, they share many common experiences and observations about what has enabled them to succeed and what continues to challenge them in their work. The primary purpose of this research is to deepen understanding of successful INGOs so that they can be better supported and established in other communities.